Changes in Retinal Oxygen Saturation 1 Month After Femtosecond LASIK Treatment in Chinese Adults with Myopia

Xiaoqi Ma; Shanshan Ge; Xinwei Yang; Yuehua Zhou

doi:10.1007/s40123-024-01091-x

Changes in Retinal Oxygen Saturation 1 Month After Femtosecond LASIK Treatment in Chinese Adults with Myopia

Ophthalmol Ther. 2025 Jan 21. doi: 10.1007/s40123-024-01091-x. Online ahead of print.

Authors

Xiaoqi Ma^{1

2}, Shanshan Ge³, Xinwei Yang^{1

2}, Yuehua Zhou^{4

5

6

7}

Affiliations

¹ Eye School of Chengdu, University of Traditional Medicine, Chengdu, 510100, Sichuan Province, China.
² Ineye Hospital of Chengdu University of Traditional Medicine, Chengdu, 510100, Sichuan Province, China.
³ Beijing Ming Vision & ophthalmology, Beijing, 110000, China.
⁴ Eye School of Chengdu, University of Traditional Medicine, Chengdu, 510100, Sichuan Province, China. [email protected].
⁵ Beijing Ming Vision & ophthalmology, Beijing, 110000, China. [email protected].
⁶ Ineye Hospital of Chengdu University of Traditional Medicine, Chengdu, 510100, Sichuan Province, China. [email protected].
⁷ Department of Beijing Ming Vision & Ophthalmology, Ineye Hospital of Chengdu University of TCM, 16th Floor, Bianyifang Building, No.16 Chongwenmenwai Street, Dongcheng District, Beijing, 100000, China. [email protected].

PMID: 39836318
DOI: 10.1007/s40123-024-01091-x

Abstract

Introduction: This study aimed to compare changes in retinal oxygen saturation 1 month after femtosecond-assisted laser in situ keratomileusis (FS-LASIK) in Chinese adults with myopia using retinal oximetry.

Methods: In this prospective, observational, single-center cohort study, Chinese adults aged 18-45 years with myopia were categorized into four groups according to spherical equivalent (SE), with 66 eyes characterized as low myopia (LM -3.00D < SE ≤ -0.50D), 68 eyes as moderate myopia (MM -6.00D < SE ≤ -3.00D), 68 eyes as high myopia (HM -9.00D < SE ≤ -6.00D), and 65 eyes as super-high myopia (SHM: SE ≤ -9.00D). The following were measured before and 1 month after FS-LASIK: SE, intraocular pressure (IOP), average keratometry (Km), and axial length (AL). Other ocular biological parameters included retinal arterial oxygen saturation (SaO₂) and retinal venous oxygen saturation (SvO₂); parameter difference values are expressed as ∆.

Results: Of the 267 participants, 63.30% were female and 36.70% were male. The mean SE, AL, SaO₂, and SvO₂ were -5.93 ± 3.24 D, 26.01 ± 1.35 mm, 93.49% ± 1.67%, and 62.97% ± 4.52%, respectively. Before FS-LASIK, SaO₂ was significantly correlated with AL and SE (r_s = -0.305, P < 0.001; r_s = 0.385, P < 0.001). Significant differences were found in SaO₂ across myopia categories (P < 0.001). The changes in the retinal arterial oxygen saturation decreased significantly after FS-LASIK (F = 24.948, P < 0.001). After surgery, SaO₂ demonstrated a statistically significant but weak negative relationship with refractive correction (ΔSE) (r_s = -0.380, P < 0.001) and axial length (r_s = -0.404, P < 0.001), a significant but weak positive correlation with average keratometry cutting value (ΔKm) (r_s = 0.354, P < 0.001), and no correlation with the change in IOP (ΔIOP) (P > 0.05).

Conclusion: Ruling out the influence of refractive error, SaO₂ was significantly decreased 1 month after FS-LASIK, while there was no significant change in SvO₂. We conjecture that retinal amplification may affect differences in retinal oxygen saturation.

Keywords: Axial length; Corneal refractive surgery; Myopia; Retinal amplification; Retinal oxygen saturation.