Selective Synthesis of Amines by Heterogeneous Co Catalysts via Borrowing Hydrogen Protocols

Endah Suarsih; Yusuke Kita; Keigo Kamata; Michikazu Hara

doi:10.1021/acs.orglett.4c04633

Selective Synthesis of Amines by Heterogeneous Co Catalysts via Borrowing Hydrogen Protocols

Org Lett. 2025 Jan 21. doi: 10.1021/acs.orglett.4c04633. Online ahead of print.

Authors

Endah Suarsih^{1

2}, Yusuke Kita³, Keigo Kamata^{1

2}, Michikazu Hara^{1

2}

Affiliations

¹ Laboratory for Materials and Structures, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan.
² Materials and Structures Laboratory, Institute of Integrated Research, Institute of Science Tokyo, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan.
³ Catalytic Organic Chemistry Laboratory, Graduate School of Engineering, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 545-0051, Japan.

PMID: 39837765
DOI: 10.1021/acs.orglett.4c04633

Abstract

Developed Co-MgO/TiO₂ was applicable to C-N bond formation by direct amination of primary and secondary alcohols with NH₃ via a borrowing hydrogen protocol. Selective synthesis of primary, secondary, and tertiary amines was achieved by controlling the reaction conditions. Asymmetric secondary amines can be synthesized by the coupling of alcohols and amines.