Cellulose-based delivery systems for bioactive ingredients: A review

Considering the outstanding advantages including abundant resources, structure-performance designability, impressive mechanical strength, and 3D network structure-forming ability, cellulose is an ideal material for encapsulating bioactive ingredients. Due to its low solubility in water, large-scaled morphology and poor flexibility, cellulose is unsuitable for the construction of carriers. Consequently, the majority of cellulose is employed following physical or chemical modification. Cellulose and its derivatives are extensively employed in the food industry, including fat replacement, food packaging composites, food additives, 3D-printed food and delivery systems. Their benefits in food delivery systems are particularly pronounced. Therefore, the distinguishing features, preparation methods, recent developments and effectiveness of different cellulose-based delivery systems for bioactive ingredients are discussed. Cellulose-based delivery systems offer unique advantages in terms of environmental impact reduction, modification facilitation, stimuli-responsive release as well as tailored design, and their application has gained widespread recognition. However, they are facing challenges in the application process comprising modification methods for cellulose-based materials, new methods for commercial preparation on a wide scale, cellulose-based multifunctional conveyance systems and systematic evaluation using in vivo experiments. In conclusion, this review provides theoretical references for the development of novel delivery carriers as well as the efficient application and popularization of cellulose-based delivery systems.