Comparative study on the anti-alcoholic liver disease efficiency of the ethanol- and water-soluble polysaccharides from Baijiu vinasses

Yizhou Liu; Qingxi Ren; Hui Qin; Mengyang Huang; Jian Mao; Beidou Xi; Suyi Zhang

doi:10.1016/j.ijbiomac.2025.140087

Comparative study on the anti-alcoholic liver disease efficiency of the ethanol- and water-soluble polysaccharides from Baijiu vinasses

Int J Biol Macromol. 2025 Jan 20:140087. doi: 10.1016/j.ijbiomac.2025.140087. Online ahead of print.

Authors

Yizhou Liu¹, Qingxi Ren², Hui Qin³, Mengyang Huang³, Jian Mao⁴, Beidou Xi⁵, Suyi Zhang³

Affiliations

¹ Luzhou Laojiao Co, Ltd, Luzhou, Sichuan 646000, China; National Engineering Research Center of Solid-State Brewing, Luzhou, Sichuan 646000, China; School of Environmental Science and Engineering, Tianjin University, Tianjin 300350, China.
² School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
³ Luzhou Laojiao Co, Ltd, Luzhou, Sichuan 646000, China; National Engineering Research Center of Solid-State Brewing, Luzhou, Sichuan 646000, China.
⁴ School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address: [email protected].
⁵ School of Environmental Science and Engineering, Tianjin University, Tianjin 300350, China; State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.

PMID: 39842569
DOI: 10.1016/j.ijbiomac.2025.140087

Abstract

Ethanol- and water-soluble polysaccharides were extracted from Baijiu vinasses (EP and WP), respectively. EP was dominantly composed by arabinose, glucose and xylose with molar ratio of 8.81: 76.82: 6.9. While, WP was dominantly composed by galactose, glucose and mannose with molar ratio of 8.32: 56.05: 25.19. The molecular weights and reducing sugar contents in EP and WP were 6.2 kDa vs. 16.1 kDa and 24.52 ± 0.97 % vs. 19.77 ± 0.75 %, respectively. Alterations in activation of the Nrf2/HO-1 signalling pathway and increases in the abundance of Lachnospiraceae and Akkermansia and their associated metabolisms could be the general mechanism by which Baijiu vinasses (BV) polysaccharides alleviated alcohol-induced liver disease (ALD) in mice. Due to the different physicochemical characteristics, the ALD alleviation efficiency was different. EP exhibited higher efficiency in oxidative stress suppressing and lipid alternation by activating the peroxisome proliferators-activated receptors (PPAR) signalling pathway. WP exhibited higher efficiency in liver damage repairing with the controlment in tryptophan metabolism pathway. This study exhibited the potential biofunction of BV polysaccharides in ALD alleviation and could promote the BV upcycling.

Keywords: Alcoholic liver diseases; Baijiu vinasses; Intestinal microbiota composition; Metabolization; Nrf2/HO-1 signalling pathways; Polysaccharides.