Thyrotoxic periodic Paralysis With hypoxemia: A case report and a comprehensive review

Radiol Case Rep. 2024 Dec 30;20(3):1601-1604. doi: 10.1016/j.radcr.2024.12.033. eCollection 2025 Mar.

Abstract

Hyperthyroidism is linked to several muscle disorders, including thyrotoxic myopathy, myasthenia gravis, and periodic paralysis. Thyrotoxic periodic paralysis (TPP) is a rare and potentially life-threatening neuromuscular condition that predominantly affects Asian males and is characterized by muscle weakness, hypokalemia, and thyrotoxicosis. Treatment involves potassium supplementation, and beta-blockers. In rare cases, recurrent muscle weakness episodes can impact the respiratory muscles, potentially leading to acute respiratory failure. This case represents the first documented instance of TPP associated with multiple hypoxemia episodes.

Keywords: Hyperthyroidism; Hypoxemia; Thyrotoxic periodic paralysis.

Publication types

  • Case Reports