Advances in dietary polyphenols: Regulation of inflammatory bowel disease (IBD) via bile acid metabolism and the gut-brain axis

Kexin Jiang; Yinuo Bai; Ruyan Hou; Guijie Chen; Lingyi Liu; Ozan N Ciftci; Mohamed A Farag; Lianliang Liu

doi:10.1016/j.foodchem.2025.142932

Advances in dietary polyphenols: Regulation of inflammatory bowel disease (IBD) via bile acid metabolism and the gut-brain axis

Food Chem. 2025 Jan 20:472:142932. doi: 10.1016/j.foodchem.2025.142932. Online ahead of print.

Authors

Kexin Jiang¹, Yinuo Bai¹, Ruyan Hou², Guijie Chen², Lingyi Liu³, Ozan N Ciftci³, Mohamed A Farag⁴, Lianliang Liu⁵

Affiliations

¹ State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Animal Protein Deep Processing Technology of Zhejiang, Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, College of Food Science and Engineering, Ningbo University, Ningbo, Zhejiang, China.
² State Key Laboratory of Tea Plant Biology and Utilization, Key Laboratory of Food Nutrition and Safety, School of Tea and Food Science & Technology, Anhui Agricultural University, Hefei 230036, China.
³ Department of food science and technology, University of Nebraska, Lincoln 68588, NE, USA.
⁴ Pharmacognosy department, faculty of Pharmacy, Cairo University, 11562, Egypt.
⁵ State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Animal Protein Deep Processing Technology of Zhejiang, Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, College of Food Science and Engineering, Ningbo University, Ningbo, Zhejiang, China. Electronic address: [email protected].

PMID: 39862607
DOI: 10.1016/j.foodchem.2025.142932

Abstract

Dietary polyphenols represent a diverse group of plant-derived compounds known for their extensive biological activities, offering significant promise in the prevention and treatment of various chronic illnesses. Despite their potential, advancements in their research have been curtailed by challenges in structural analysis and limitations in existing research models. This review marks a pioneering exploration into how bile acids, gut microbiota, and the gut-brain axis serve as conduits through which dietary polyphenols can exert therapeutic effects on Inflammatory Bowel Disease (IBD). This review enriches understanding of their biological functions and addresses common obstacles in the study of natural polyphenols. It provides a comprehensive examination of the role of dietary polyphenols in modulating bile acid metabolism and mitigating IBD, covering aspects such as polyphenols, bile acid metabolism, oxidative stress, inflammation, and the nervous system. This work opens new vistas in appreciating the full spectrum of polyphenol benefits, laying the groundwork for future explorations in this domain.

Keywords: Bile acids; Dietary polyphenols; Enterohepatic circulation; Gut microbiota; Gut-brain axis; Inflammatory bowel disease (IBD).

Publication types

Review