Exploring the potential of advanced artificial intelligence technology in predicting microsatellite instability (MSI) and Ki-67 expression of endometrial cancer (EC) is highly significant. This study aimed to develop a novel hybrid radiomics approach integrating multiparametric magnetic resonance imaging (MRI), deep learning, and multichannel image analysis for predicting MSI and Ki-67 status. A retrospective study included 156 EC patients who were subsequently categorized into MSI and Ki-67 groups. The hybrid radiomics model (HMRadSum) was developed by extracting quantitative imaging features and deep learning features from multiparametric MRI using emerging attention mechanism. Tumor markers were subsequently predicted utilizing an XGBoost classifier. Model performance and interpretability were evaluated using standard classification metrics, Gradient-weighted Class Activation Mapping (Grad-CAM), and SHapley Additive exPlanations (SHAP) techniques. For the MSI prediction task, the HMRadSum model achieved area-under-curve (AUC) value of 0.945 (95% CI 0.862-1.000) and accuracy of 0.889. For the Ki-67 prediction task, the AUC and accuracy of HMRadSum model was 0.888 (95% CI 0.743-1.000) and 0.810. This hybrid radiomics model effectively extracted features associated with EC gene expression, providing potential clinical implications for personalized diagnosis, treatment, and treatment strategy optimization.
Keywords: Attention mechanism; Endometrial cancer; Machine learning; Radiomics; SHAP analysis.
© 2025. The Author(s).