Corneal penetration and metabolism of the antiherpetic 5-iodo-2'-deoxycytidine

Curr Eye Res. 1985 May;4(5):627-9. doi: 10.3109/02713688508999995.

Abstract

The study of the permeability of the cornea to 5-iodo-2'-deoxycytidine (IDC), an antiherpetic agent was performed in the rabbit. In a first experiment, using 125I-IDC eye-drops and a sustained contact between the drug and the cornea, we showed that the penetration of IDC in the aqueous humor was important. In a second experiment, using a HPLC method, we studied comparative ocular penetration and metabolism of IDC and 5-iodo-2'-deoxyuridine (IDU).

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antiviral Agents / metabolism*
  • Bromodeoxycytidine / analogs & derivatives
  • Chromatography, High Pressure Liquid
  • Cornea / metabolism*
  • Deoxycytidine / analogs & derivatives*
  • Deoxycytidine / metabolism
  • Herpesviridae / drug effects
  • Idoxuridine / metabolism
  • Male
  • Ophthalmic Solutions
  • Permeability
  • Rabbits
  • Radioisotopes

Substances

  • Antiviral Agents
  • Ophthalmic Solutions
  • Radioisotopes
  • Deoxycytidine
  • Bromodeoxycytidine
  • ibacitabine
  • Idoxuridine