Effect of diazepam on drug absorption and gastric emptying in man

Br J Anaesth. 1985 Nov;57(11):1107-9. doi: 10.1093/bja/57.11.1107.

Abstract

Paracetamol 20 mg kg-1 dissolved in 200 ml of water was given by mouth to seven healthy volunteers, together with a single i.v. dose of diazepam 0.2 mg kg-1 or saline 0.04 ml kg-1. This study demonstrated that the rate of paracetamol absorption was not significantly changed by diazepam, indicating that there was no delay in gastric emptying attributable to diazepam per se.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Acetaminophen / blood
  • Acetaminophen / metabolism
  • Adult
  • Diazepam / pharmacology*
  • Female
  • Gastric Emptying / drug effects*
  • Humans
  • Intestinal Absorption / drug effects*
  • Male
  • Time Factors

Substances

  • Acetaminophen
  • Diazepam