Abstract
The addition of mercaptobenzene to cinnamic acids yielded 3-phenyl-3-phenylthiopropionic acids which were then converted to the amides. The latter compounds were reduced to the amines with lithium aluminum hydride. Some of the obtained amides displayed significant biological activity.
MeSH terms
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Analgesics / chemical synthesis
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Analgesics / toxicity
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Animals
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Anticonvulsants / chemical synthesis
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Apomorphine / antagonists & inhibitors
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Behavior, Animal / drug effects*
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Lethal Dose 50
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Male
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Mice
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Motor Activity / drug effects
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Muscle Contraction / drug effects
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Pentylenetetrazole / antagonists & inhibitors
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Phenylpropionates / chemical synthesis*
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Phenylpropionates / toxicity
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Postural Balance / drug effects
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Rats
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Rats, Inbred Strains
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Reserpine / antagonists & inhibitors
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Stereotyped Behavior / drug effects
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Structure-Activity Relationship
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Tryptamines / administration & dosage
Substances
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Analgesics
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Anticonvulsants
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Phenylpropionates
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Tryptamines
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tryptamine
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3-phenylpropionic acid
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Reserpine
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Apomorphine
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Pentylenetetrazole