On the reactions of DL-1,3-dimethylthymine epoxide with amines and L-amino acid derivatives

Nucleic Acids Symp Ser. 1985:(16):73-6.

Abstract

Reaction of DL-1,3-dimethylthymine epoxide (1) with aniline gave (2A) and (3A). Isomerization of (2A) provided (3A), (4) and (5). Reaction of (1) with L-amino acid ethyl ester afforded four optically active diastereomers.

MeSH terms

  • Amines*
  • Amino Acids*
  • Chemical Phenomena
  • Chemistry
  • Isomerism
  • Structure-Activity Relationship
  • Thymine / analogs & derivatives*

Substances

  • Amines
  • Amino Acids
  • 1,3-dimethylthymine epoxide
  • Thymine