Trisomy 21 mosaicism in a woman with two children with trisomy 21 Down's syndrome

J Med Genet. 1974 Dec;11(4):378-9. doi: 10.1136/jmg.11.4.378.

Abstract

Trisomy 21 mosaicism was identified by fluorescent quinacrine banding in a phenotypically normal mother, who gave birth to two children with trisomy 21 Down's syndrome.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Child
  • Chromosomes, Human, 21-22 and Y*
  • Down Syndrome / genetics*
  • Extrachromosomal Inheritance
  • Female
  • Humans
  • Male
  • Maternal Age
  • Microscopy, Fluorescence
  • Mosaicism*
  • Phenotype
  • Staining and Labeling
  • Trisomy*