Conjunctival biopsy in the diagnosis of sarcoidosis

South Med J. 1979 Feb;72(2):124-6. doi: 10.1097/00007611-197902000-00005.

Abstract

The diagnosis of sarcoidosis with ocular involvement is often difficult and accompanied by a certain measure of uncertainty due to a paucity of additional physical signs. In the ophthalmic literature, it is controversial as to whether biopsy of a clinically normal conjuctiva should be done if sarcoidosis is suspected. Many authors advocate biopsy only in the presence of conjunctival follicles or nodules. However, a positive biopsy from a clinically normal-appearing conjunctiva has been reported. Recently, we saw a patient with bilateral uveitis, evanescent cranial nerve palsies, and other clinical manifestations suggesting central nervous system and ocular sarcoidosis. Random biopsy of a normal-appearing conjunctiva revealed a noncaseating granuloma consistent with sarcoidosis. Since conjunctival biopsy is a simple office procedure with minimal morbidity, this diagnostic tool should be considered for patients with clinically suspected sarcoidosis, even in the absence of conjunctival follicles or nodules.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Conjunctiva / pathology*
  • Eye Diseases / pathology
  • Female
  • Humans
  • Sarcoidosis / pathology*
  • Uveitis / pathology