Abstract
Waterworth, Pamela M., Lockey, Eunice, Berry, E. M., and Pearce, Helen M. (1974).Thorax, 29, 432-436. A critical investigation into the antibiotic sterilization of heart valve homografts. Sterility tests of homograft heart valves sterilized by antibiotics were found to be invalidated by carry-over of the antibiotics. A method was devised to test the efficacy of different antibiotic mixtures using membrane filters. Fifty-five organisms, including 13 species, were tested, and sterility was achieved with only 35.
MeSH terms
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Alcaligenes
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Aminoglycosides / pharmacology
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Animals
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Anti-Bacterial Agents / pharmacology*
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Aortic Valve / transplantation*
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Bicarbonates
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Cattle / immunology
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Enterococcus faecalis / drug effects
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Erythromycin / pharmacology
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Gentamicins / pharmacology
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Humans
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Immune Sera
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Methicillin / pharmacology
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Neomycin / pharmacology
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Nystatin / pharmacology
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Penicillins / pharmacology
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Polymyxins / pharmacology
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Proteus / drug effects
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Pseudomonas aeruginosa / drug effects
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Sodium
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Staphylococcus / drug effects
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Sterilization*
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Sulfates
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Transplantation, Homologous
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Bicarbonates
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Gentamicins
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Immune Sera
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Penicillins
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Polymyxins
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Sulfates
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Nystatin
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Erythromycin
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Sodium
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Neomycin
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Methicillin