Pyrrolo(4,3,2-de)isoquinolines with central nervous system and antihypertensive activities

J Med Chem. 1974 Nov;17(11):1140-5. doi: 10.1021/jm00257a003.
No abstract available

MeSH terms

  • Animals
  • Antihypertensive Agents / pharmacology*
  • Blepharoptosis / chemically induced
  • Blood Pressure / drug effects
  • Brain / drug effects
  • Brain / enzymology
  • Central Nervous System / drug effects*
  • Dose-Response Relationship, Drug
  • Epinephrine / antagonists & inhibitors
  • Female
  • Injections, Intraperitoneal
  • Isoquinolines / pharmacology*
  • Lethal Dose 50
  • Male
  • Mice
  • Monoamine Oxidase Inhibitors / pharmacology
  • Myocardium / enzymology
  • Pyrroles / pharmacology
  • Rats
  • Reserpine / antagonists & inhibitors
  • Tyramine / pharmacology

Substances

  • Antihypertensive Agents
  • Isoquinolines
  • Monoamine Oxidase Inhibitors
  • Pyrroles
  • Reserpine
  • Tyramine
  • Epinephrine