Abstract
Either L-dopa, in combination with 1-alpha-methyldopa hydrazine (MK-486), or 1-(2''-pyrimidyl)-4-piperonylpiperazine, an agent that stimulates dopamine receptors, relieves surgically induced tremor in monkeys and concomitantly evokes involuntary movements. These results indicate that tremor and involuntary movements are associated with a common mechanism and that the activity of the dopamine receptors is involved in the regulation of these dysfunctions.
MeSH terms
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5-Hydroxytryptophan / pharmacology
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Animals
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Benzyl Compounds / pharmacology
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Benzyl Compounds / therapeutic use
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Dihydroxyphenylalanine / administration & dosage
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Dihydroxyphenylalanine / pharmacology*
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Dihydroxyphenylalanine / therapeutic use
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Dioxoles / pharmacology
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Dioxoles / therapeutic use
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Drug Interactions
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Electroencephalography
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Haloperidol / pharmacology
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Haplorhini
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Humans
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Hydrazines / pharmacology
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Hydrazines / therapeutic use
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Hyperkinesis / chemically induced*
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Injections, Intraperitoneal
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Methyldopa / administration & dosage
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Methyldopa / pharmacology
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Methyldopa / therapeutic use
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Methyltyrosines / pharmacology
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Picolinic Acids / pharmacology
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Piperazines / administration & dosage
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Piperazines / pharmacology*
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Piperazines / therapeutic use
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Pyrimidines / administration & dosage
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Pyrimidines / pharmacology*
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Pyrimidines / therapeutic use
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Tremor / drug therapy*
Substances
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Benzyl Compounds
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Dioxoles
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Hydrazines
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Methyltyrosines
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Picolinic Acids
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Piperazines
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Pyrimidines
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Methyldopa
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Dihydroxyphenylalanine
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5-Hydroxytryptophan
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Haloperidol