Abstract
Aqueous extracts of Pteryxia terebinthina var. terebinthina were shown to possess antiarrhythmic activity. A novel furanocoumarin, pterybinthinone, the known coumarins pteryxin and umbelliferone, and sucrose were isolated from this plant. Attempts to re-isolate a structurally undefined, defibrillatory substance by means of a published protocol were unsuccessful.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aconitum / antagonists & inhibitors
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Animals
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Anti-Arrhythmia Agents / isolation & purification*
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Arrhythmias, Cardiac / chemically induced
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Arrhythmias, Cardiac / drug therapy
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Cats
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Coumarins / isolation & purification
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Coumarins / pharmacology
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In Vitro Techniques
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Ouabain / antagonists & inhibitors
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Plant Extracts / pharmacology
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Plants / analysis*
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Rabbits
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Rats
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Umbelliferones / isolation & purification
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Umbelliferones / pharmacology
Substances
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Anti-Arrhythmia Agents
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Coumarins
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Plant Extracts
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Umbelliferones
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pteryxin
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Ouabain
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pterybinthinone