Molecular structure of a left-handed double helical DNA fragment at atomic resolution

A H Wang; G J Quigley; F J Kolpak; J L Crawford; J H van Boom; G van der Marel; A Rich

doi:10.1038/282680a0

Molecular structure of a left-handed double helical DNA fragment at atomic resolution

Nature. 1979 Dec 13;282(5740):680-6. doi: 10.1038/282680a0.

Authors

A H Wang, G J Quigley, F J Kolpak, J L Crawford, J H van Boom, G van der Marel, A Rich

PMID: 514347
DOI: 10.1038/282680a0

Abstract

The DNA fragment d(CpGpCpGpCpG) crystallises as a left-handed double helical molecule with Watson-Crick base pairs and an antiparallel organisation of the sugar phosphate chains. The helix has two nucleotides in the asymmetric unit and contains twelve base pairs per turn. It differs significantly from right-handed B-DNA.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Base Sequence
Crystallization
DNA*
Hydrogen Bonding
Nucleic Acid Conformation
Polydeoxyribonucleotides
Structure-Activity Relationship
X-Ray Diffraction

Substances

Polydeoxyribonucleotides
DNA