Abstract
The anticancer activity of the roots of Ervatamia heyneana (Apocynaceae) was found to be due principally to the known alkaloid, camptothecin (1). The closely related, but less active, 9-methoxycamptothecin (2) was also obtained. This is the first reported isolation of these biogenetically interesting alkaloids from the indole alkaloid rich Apocynaceae.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Camptothecin / analogs & derivatives*
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Camptothecin / isolation & purification*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Plants / analysis*
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Spectrophotometry, Ultraviolet
Substances
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Antineoplastic Agents, Phytogenic
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Camptothecin