Effect of group-A meningococcal vaccine in army recruits in Finland

Lancet. 1975 Nov 8;2(7941):883-6. doi: 10.1016/s0140-6736(75)92125-x.

Abstract

During an epidemic caused by group-A, sulphonamide-resistant meningococci in Finland, group-A polysaccharide vaccine was administered in 1974 to 16 458 recruits of the Armed Forces, leaving 20 748 as controls. Specific antibody response was good, and after vaccination only 1% of the men were without anti-meningococcal group-A antibodies. Pharyngeal carriage of the epidemic strain was low, about 1-5%, in the men when entering service. Group-A meningococcal disease occurred during the nine months' mean observation period in 1 of the vaccinated men (an annual incidence of 11 per 100 000) and in 8 of those not vaccinated (71 per 100 000), indicating 89% protective effect of the vaccine. Furthermore, the total number of cases of group-A meningococcal disease was reduced to non-epidemic levels at a time when 36% of the men in service were vaccinated, and has remained low for the next twelve months even though the epidemic in the general population continued.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Antibodies, Bacterial / isolation & purification
  • Bacterial Vaccines / administration & dosage*
  • Carrier State
  • Disease Outbreaks / epidemiology*
  • Evaluation Studies as Topic
  • Finland
  • Humans
  • Immunization Schedule
  • Male
  • Meningitis, Meningococcal / epidemiology
  • Meningitis, Meningococcal / prevention & control*
  • Military Medicine
  • Neisseria meningitidis* / immunology
  • Polysaccharides, Bacterial / therapeutic use*
  • Seasons
  • Time Factors
  • Vaccination

Substances

  • Antibodies, Bacterial
  • Bacterial Vaccines
  • Polysaccharides, Bacterial