Abstract
Montanin (1) and spruceanol (2), two quite different diterpenes, were found to be responsible for the cytotoxic and antitumor activity of the root and root bark of Cunuria spruceana (Euphorbiaceae). The structure of spruceanol (2) was deduced from spectral interpretation and chemical correlation with 12-methoxycleistanth-8,11,13-trien-3-one (4).
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Abietanes
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Acetylation
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Animals
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Chemical Phenomena
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Chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Hydrogenation
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In Vitro Techniques
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Leukemia P388 / drug therapy
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Methylation
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Oxidation-Reduction
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Plants, Medicinal / analysis*
Substances
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Abietanes
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Montanin
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Spruceanol