Abstract
A synthesis of esters from 1,2,3,3-tetramethyl-2-azabicyclo[2.2.2]octan-5-endo-ol lithium slat and acyl chlorides is described. A number of these compounds showed strong antiarrhythmic, local anesthetic and hypotensive activities.
MeSH terms
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Anesthetics / chemical synthesis*
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Animals
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Anti-Arrhythmia Agents / chemical synthesis*
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Anti-Arrhythmia Agents / therapeutic use
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Azocines / chemical synthesis*
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Azocines / therapeutic use
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Bridged Bicyclo Compounds / chemical synthesis*
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Bridged Bicyclo Compounds / therapeutic use
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Bridged-Ring Compounds / chemical synthesis*
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Guinea Pigs
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Heart / drug effects
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Hypertension / drug therapy
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Mice
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Rats
Substances
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Anesthetics
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Anti-Arrhythmia Agents
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Azocines
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Bridged Bicyclo Compounds
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Bridged-Ring Compounds