28 patients with head and neck tumors not suitable for definitive treatment with radiation or surgery were treated with cis-diamminedichloroplatinum (II) and bleomycin in combination. Of 24 adequately treated patients, there were 3 partial remissions lasting for 3,3 and 6 months, respectively. Toxicity of the regimen as given was substantial; 13 patients showed some evidence of nephrotoxicity and there were 2 drug deaths related to progressive renal failure. 1 patient developed bleomycin pulmonary toxicity.