Regional distribution of neurotransmitter receptors in the visual structures of the rat brain

Biomed Biochim Acta. 1984;43(10):1119-25.

Abstract

The regional distribution of the binding of 3H-quinuclidinyl benzylate, 3H-dihydroergocryptine, 3H-dihydroalprenolol, 3H-serotonin and 3H-flunitrazepam was investigated in the retina, lateral geniculate nucleus, superior colliculus, visual and frontal cortex of 25-day-old and adult rats. In adult rats the highest binding levels for the muscarinic acetylcholine and benzodiazepine receptor are present in the visual and frontal cortex, whereas alpha- and beta-adrenergic receptor binding was highest in the retina and 3H-serotonin binding in the lateral geniculate nucleus. Binding of 3H-quinuclidinyl benzylate, 3H-flunitrazepam and 3H-serotonin increases in the adult rats, whereas alpha- and beta-adrenergic receptor binding is decreased compared to the binding levels found in 25-day-old animals. The distribution of the neurotransmitter receptors studied within the visual structures cannot be readily correlated with the pattern of some neurochemical presynaptic parameters.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Chemistry*
  • Female
  • Frontal Lobe / analysis
  • Geniculate Bodies / analysis
  • Male
  • Rats
  • Receptors, Adrenergic / analysis*
  • Receptors, GABA-A / analysis*
  • Receptors, Muscarinic / analysis*
  • Receptors, Serotonin / analysis*
  • Retina / analysis
  • Superior Colliculi / analysis
  • Visual Cortex / analysis

Substances

  • Receptors, Adrenergic
  • Receptors, GABA-A
  • Receptors, Muscarinic
  • Receptors, Serotonin