Danger of withdrawal of vasodilator therapy in patients with chronic heart-failure

Lancet. 1980 Apr 5;1(8171):735-6. doi: 10.1016/s0140-6736(80)91232-5.

Abstract

Ten patients with severe congestive heart-failure were treated with a vasodilator, prazosin, in addition to diuretics; their exercise capacity was assessed by testing on a treadmill. After the withdrawal of prazosin the condition of three patients deteriorated markedly.

MeSH terms

  • Acute Disease
  • Aged
  • Drug Administration Schedule
  • Exercise Test
  • Female
  • Heart Failure / drug therapy*
  • Heart Failure / physiopathology
  • Heart Function Tests
  • Heart Rate
  • Humans
  • Male
  • Middle Aged
  • Prazosin / administration & dosage*
  • Prazosin / therapeutic use
  • Quinazolines / administration & dosage*

Substances

  • Quinazolines
  • Prazosin