Abstract
Microinjection of L-glutamate into the intermediate nucleus tractus solitarii in anesthetized rats elicits hypotension, bradycardia, and apnea, simulating baroreceptor reflexes. Ablation of the nodose ganglion results in selective reduction of high-affinity uptake of L-glutanate in the nucleus tractus solitarii. L-Glutamate may be the neurotransmitter of afferent nerve fibers from arterial baroreceptors.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Afferent Pathways / physiology
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Animals
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Blood Pressure / drug effects
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Brain Mapping
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Glutamates / pharmacology
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Glutamates / physiology*
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Heart Rate / drug effects
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Kainic Acid / pharmacology
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Medulla Oblongata / physiology*
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Neurotransmitter Agents / physiology*
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Pressoreceptors / physiology*
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Rats
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Reflex / drug effects
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Respiration / drug effects
Substances
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Glutamates
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Neurotransmitter Agents
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Kainic Acid