The emergence of ORG NC 45, 1- [2 beta,3 alpha,5 alpha,16 beta,17 beta)-3, 17-bis(acetyloxy)-2-(1-piperidinyl)-androstan-16-yl]-1-methylpiperidinium bromide, from the pancuronium series

Br J Anaesth. 1980:52 Suppl 1:3S-9S. doi: 10.1093/bja/52.suppl_1.3s.

Abstract

A novel approach is described for obtaining a drug that will be a potent non-depolarizing neuromuscular blocking agent with the potential for a short duration of action and little cumulative effect. This approach led to the discovery of Org NC 45, from the pancuronium series.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cats
  • Chemical Phenomena
  • Chemistry
  • Chemistry, Pharmaceutical
  • Humans
  • Neuromuscular Blocking Agents
  • Pancuronium / analogs & derivatives*
  • Pancuronium / pharmacology
  • Rats
  • Structure-Activity Relationship
  • Vagus Nerve / drug effects
  • Vecuronium Bromide

Substances

  • Neuromuscular Blocking Agents
  • Vecuronium Bromide
  • Pancuronium