Abstract
(+/-)-1-(Isopropylamino)-3-[p-(2-cyclopropyl-methoxyethyl)-phenoxy]-2-propanol HCl (betaxolol, SL 75212) was given to groups of healthy volunteers, 10 mg daily for 7 days followed by 20 mg daily 7 days in one group, and increasing daily doses up to 60 mg/day for a total of 15 days in the other group. The pharmacokinetics were studied during dosing and in the washout period. The pharmacokinetic characteristics were unchanged after repeated doses, T/2 16-22 h, Vd 7.7-8.8 l/kg; clearance 0.28-0.33 l/h/kg.
Publication types
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Clinical Trial
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Controlled Clinical Trial
MeSH terms
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Administration, Oral
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Adrenergic beta-Antagonists / administration & dosage
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Adrenergic beta-Antagonists / metabolism*
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Adrenergic beta-Antagonists / pharmacology
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Adult
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Betaxolol
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Blood Pressure / drug effects
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Heart Rate / drug effects
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Humans
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Kinetics
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Male
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Physical Exertion
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Propanolamines / administration & dosage
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Propanolamines / metabolism*
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Propanolamines / pharmacology
Substances
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Adrenergic beta-Antagonists
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Propanolamines
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Betaxolol