Abstract
Precursors of cytotoxic lymphoid cells obtained from mice treated with cyclophosphamide (CY) can be expanded in culture by alloantigens in the presence of purified human interleukin 2 (IL 2). Similarly, IL 2 delivered in vivo in a rate-controlled manner enhances cytotoxic activity in mice that are immunosuppressed by high doses of CY. The effector cells are Thy-1.2+ and are not elicited in the absence of antigen.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antigens, Surface / analysis
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Cyclophosphamide / pharmacology*
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Drug Resistance
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Interleukin-2 / pharmacology*
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Isoantigens / immunology
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Inbred DBA
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T-Lymphocytes, Cytotoxic / drug effects
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T-Lymphocytes, Cytotoxic / immunology*
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Thy-1 Antigens
Substances
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Antigens, Surface
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Interleukin-2
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Isoantigens
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Thy-1 Antigens
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Cyclophosphamide