Abstract
The antinociceptive profiles of mu- and kappa-opiate agonists were determined in a combined tail immersion plus tail pressure nociceptive test in rats. Combined analysis of potencies for pressure against heat noxia enabled differentiation between all mu- and kappa-agonists tested, thus confirming previous studies in other animal species and paralleling observations from studies on isolated tissue preparations. The distinct antinociceptive profiles produced by mu- and kappa-agonists provide further quantitative evidence that these agents are behaviourally different.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics, Opioid / pharmacology*
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Animals
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Cyclazocine / analogs & derivatives
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Cyclazocine / pharmacology
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Dose-Response Relationship, Drug
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Ethylketocyclazocine* / analogs & derivatives*
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Hot Temperature
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Male
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Nociceptors / drug effects
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Nociceptors / physiology
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Pain / drug therapy*
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Pain / physiopathology
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Rats
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Rats, Inbred Strains
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Receptors, Opioid
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Receptors, Opioid, kappa
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Receptors, Opioid, mu
Substances
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Analgesics, Opioid
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Receptors, Opioid
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Receptors, Opioid, kappa
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Receptors, Opioid, mu
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Ethylketocyclazocine
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ketazocine
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Cyclazocine