Effects of beta-adrenoceptor blockade on prostacyclin mediated renin release in sheep

Clin Exp Pharmacol Physiol. 1984 Nov-Dec;11(6):571-7. doi: 10.1111/j.1440-1681.1984.tb00869.x.

Abstract

The effect of prostacyclin (PGI2) infusion on plasma renin concentration (PRC) was examined before and after propranolol treatment in sheep. Increasing doses of prostacyclin (0.05, 0.1 or 0.3 micrograms/kg per min) produced dose dependent increases in PRC. There was a significantly lower PRC response after propranolol at 0.3 micrograms/kg per min only.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic beta-Antagonists / pharmacology*
  • Animals
  • Blood Pressure / drug effects
  • Cardiac Output / drug effects
  • Epoprostenol / pharmacology*
  • Female
  • Hemodynamics / drug effects
  • Isoproterenol / pharmacology
  • Propranolol / pharmacology
  • Renin / blood*
  • Renin / metabolism
  • Sheep
  • Time Factors
  • Vascular Resistance / drug effects

Substances

  • Adrenergic beta-Antagonists
  • Propranolol
  • Epoprostenol
  • Renin
  • Isoproterenol