Abstract
Power spectrum analysis of heart rate fluctuations provides a quantitative noninvasive means of assessing the functioning of the short-term cardiovascular control systems. We show that sympathetic and parasympathetic nervous activity make frequency-specific contributions to the heart rate power spectrum, and that renin-angiotensin system activity strongly modulates the amplitude of the spectral peak located at 0.04 hertz. Our data therefore provide evidence that the renin-angiotensin system plays a significant role in short-term cardiovascular control in the time scale of seconds to minutes.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Angiotensins / physiology
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Animals
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Blood Pressure / drug effects
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Cardiovascular Physiological Phenomena*
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Computers
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Dogs
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Enzyme Inhibitors
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Glycopyrrolate / pharmacology
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Heart Rate* / drug effects
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Methods
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Nitroprusside / pharmacology
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Oligopeptides / pharmacology
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Parasympathetic Nervous System / physiology
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Propranolol / pharmacology
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Renin / physiology
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Sympathetic Nervous System / physiology
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Teprotide
Substances
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Angiotensins
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Enzyme Inhibitors
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Oligopeptides
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Nitroprusside
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Propranolol
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Teprotide
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Renin
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Glycopyrrolate