Abstract
The current investigations have revealed that Lewis rats preimmunized with BP in CFA, and after recovery from the first episode of EAE, developed a second mild attack of EAE after challenge with BP/CFA at specified times. However, preimmunization of Lewis rats with BP complexed to LPS in CFA protects animals for a longer time from a second attack induced by BP/CFA challenge.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Encephalomyelitis, Autoimmune, Experimental / drug therapy*
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Encephalomyelitis, Autoimmune, Experimental / pathology
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Female
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Guinea Pigs
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Immunosuppressive Agents / therapeutic use*
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Lipopolysaccharides / immunology
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Lipopolysaccharides / therapeutic use*
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Myelin Basic Protein / immunology
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Rats
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Rats, Inbred Lew
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Time Factors
Substances
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Immunosuppressive Agents
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Lipopolysaccharides
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Myelin Basic Protein