Electron immunocytochemical localization of enkephalin-like material in catecholamine-containing cells of the carotid body, the adrenal medulla, and in pheochromocytomas of man and other mammals

I M Varndell; F J Tapia; J De Mey; R A Rush; S R Bloom; J M Polak

doi:10.1177/30.7.6179985

Electron immunocytochemical localization of enkephalin-like material in catecholamine-containing cells of the carotid body, the adrenal medulla, and in pheochromocytomas of man and other mammals

J Histochem Cytochem. 1982 Jul;30(7):682-90. doi: 10.1177/30.7.6179985.

Authors

I M Varndell, F J Tapia, J De Mey, R A Rush, S R Bloom, J M Polak

PMID: 6179985
DOI: 10.1177/30.7.6179985

Abstract

Enkephalin-like immunoreactivity has been localized to electron-dense secretory granules of cat and piglet carotid bodies and adrenal medullae, horse adrenal medulla, and also to human adrenal medulla and pheochromocytomas using a gold-labeled antibody technique performed at the electron microscopic level. The same granules were also demonstrated to exhibit dopamine-beta-hydroxylase-like immunoreactivity, which suggests a granular colocalization of amines and peptides in catecholamine-storing cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adrenal Gland Neoplasms / ultrastructure*
Adrenal Medulla / ultrastructure*
Animals
Carotid Body / ultrastructure*
Catecholamines / analysis*
Cats
Dopamine beta-Hydroxylase / analysis
Endorphins / analysis*
Enkephalin, Methionine
Enkephalins / analysis*
Fluorescent Antibody Technique
Humans
Immune Sera
Microscopy, Electron
Pheochromocytoma / ultrastructure*
Staining and Labeling

Substances

Catecholamines
Endorphins
Enkephalins
Immune Sera
Enkephalin, Methionine
Dopamine beta-Hydroxylase