Cross-reactivity patterns of influenza-specific cytotoxic T lymphocytes from H-2Kb mutant mice

J Immunol. 1983 Jul;131(1):471-4.

Abstract

Limit dilution cultures were used to test for influenza immune T cell populations from bm1 and bm3 mutant mice that were not lytic for virus-infected targets expressing the Kb and Db major histocompatibility complex glycoproteins. Both Kbm3- and Kbm1-restricted cytotoxic T cells were detected. Such effectors showed minimal cross-recognition of influenza on other mutant targets, except for the case of bm1 and bm10 targets. This is dissimilar to previous findings concerning vaccinia presentation in which bm3+bm11, bm1+bm9, and bm3+bm9 pairs each showed high cross-reactivity. These differences illustrate the role of the H-2K glycoprotein in immune responsiveness. Not only are multiple determinants on each H-2K glycoprotein involved in antigen presentation, they appear to play differential roles in the presentation of different viral antigens.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cross Reactions
  • Cytotoxicity, Immunologic
  • Epitopes*
  • Genes, MHC Class II
  • H-2 Antigens / genetics
  • H-2 Antigens / immunology*
  • Mice
  • Mice, Mutant Strains
  • Orthomyxoviridae Infections / immunology*
  • Spleen / cytology
  • T-Lymphocytes, Cytotoxic / immunology*

Substances

  • Epitopes
  • H-2 Antigens
  • H-2Kb protein, mouse