Abstract
Between April, 1981, and December, 1982, 32 patients with squamous cell bronchial carcinoma were treated with a chemotherapy regimen followed by operation. The preoperative chemotherapeutic agents used were cisplatin, bleomycin, and mitomycin C. A thoracotomy was performed 3 to 4 weeks after the last day of the last treatment. Of the 29 undergoing resection, three (10.3%) had no tumor cells in the resected specimen and four (12.5%) had only a few neoplastic microcenters in tissue necrosis or fibrosis. We suggest that the use of this new chemotherapy combination with surgical resection provides excellent palliation, increases resectability, and has a potential for increasing the cure rate in squamous cell carcinoma of the lung.
MeSH terms
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bleomycin / administration & dosage
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Carcinoma, Bronchogenic / drug therapy
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Carcinoma, Bronchogenic / pathology
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Carcinoma, Bronchogenic / surgery
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Carcinoma, Bronchogenic / therapy*
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Carcinoma, Squamous Cell / drug therapy
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Carcinoma, Squamous Cell / pathology
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Carcinoma, Squamous Cell / surgery
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Carcinoma, Squamous Cell / therapy*
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Cisplatin / administration & dosage
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Combined Modality Therapy
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Female
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Humans
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Lung Neoplasms / drug therapy
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Lung Neoplasms / pathology
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Lung Neoplasms / surgery
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Lung Neoplasms / therapy*
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Male
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Middle Aged
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Mitomycin
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Mitomycins / administration & dosage
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Palliative Care
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Pneumonectomy
Substances
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Mitomycins
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Bleomycin
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Mitomycin
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Cisplatin