Lack of T cell antigen expression on hairy cells of B cell origin after in vitro exposure to PHA

Blood. 1984 Apr;63(4):958-64.

Abstract

The malignant monoclonal population in hairy cell leukemia (HCL) has been variously ascribed to be of myeloid, B, or even T cell origin. Recent data have been interpreted as suggesting that hairy cells (HC) may concomitantly or serially express both B and T surface determinants, a phenomenon which, if verified, would be unique among the lymphoproliferative malignancies. Data described here, however, demonstrate that (1) at least the majority of HCL are phenotypically of B cell derivation, and (2) the initial B cell phenotype is retained and solely expressed on cultured as well as phytohemagglutinin (PHA) activated monoclonal malignant HC.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Antigens, Surface / immunology*
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / pathology
  • Cell Separation
  • Humans
  • Leukemia, Hairy Cell / immunology*
  • Leukemia, Hairy Cell / metabolism
  • Lymphocyte Activation
  • Lymphocyte Culture Test, Mixed
  • Male
  • Middle Aged
  • Phenotype
  • Phytohemagglutinins / pharmacology
  • Rosette Formation
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / radiation effects

Substances

  • Antigens, Surface
  • Phytohemagglutinins