[Aldosterone production in vitro by angiotensin II: the role of Ca++]

Boll Soc Ital Biol Sper. 1980 Jul 15;56(13):1374-9.
[Article in Italian]

Abstract

In beef isolated and superfused adrenal glands, the Authors have studied the production of aldosteron and tissue concentration of cAMP during superfusion with angiotensin II alone or preceededby preincubation with indomethacin or verapamil. In such experimental conditions the Authors could evidence that th aldosterone-inductor effect of angiotensin II is not mediated by cAMP but by PGs and Ca++.

Publication types

  • English Abstract

MeSH terms

  • Adrenal Glands / drug effects
  • Adrenal Glands / metabolism*
  • Aldosterone / biosynthesis*
  • Angiotensin II / pharmacology*
  • Animals
  • Calcium / physiology*
  • Cattle
  • Cyclic AMP / metabolism
  • In Vitro Techniques
  • Indomethacin / pharmacology
  • Perfusion
  • Prostaglandins / physiology
  • Verapamil / pharmacology

Substances

  • Prostaglandins
  • Angiotensin II
  • Aldosterone
  • Verapamil
  • Cyclic AMP
  • Calcium
  • Indomethacin