A fatal case of active viral infection in a transplant patient is reported. On the second month post transplantation, Cytomegalovirus (CMV) infection occurred. It was attested by clinical and radiological symptoms, transient increase of transaminases and seroconversion with CMV antigen. Patient apparently recovered, but on the third month mucocutaneous Herpesvirus hominis (HVH) infection started. It was rapidly complicated by hepatitis and encephalitis which are directly responsible for the fatal outcome. A strain of HVH type 1 was easily isolated from oral and genital lesions. Immunofluorescence with HVH antiserum was positive on post mortem sample of liver biopsy Ultrastructural changes and intranuclear Herpesvirus like particles were demonstrated in liver. Etiology of hepatitis and management of immunosuppressive therapy are discussed.