Abstract
Fifty-six South Chinese individuals exhibiting IgA antibodies to EBV for 18 months and presenting nasopharyngeal abnormalities were biopsied. Four nasopharyngeal carcinomas, two at a very early stage, were detected. In 14 further individuals, without clinical or histopathological evidence of tumor, EBV/DNA internal repeats and/or EBNA were detected in the biopsied mucosae. The presence of IgA/EBV antibodies and/or EBV markers in the nasopharyngeal mucosa may characterize pre-cancerous conditions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Antibodies, Viral / analysis
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Carcinoma / microbiology
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China
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DNA Restriction Enzymes
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DNA, Viral / analysis*
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Female
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Herpesvirus 4, Human / genetics*
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Humans
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Male
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Middle Aged
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Mucous Membrane / microbiology
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Nasopharyngeal Diseases / microbiology*
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Nasopharyngeal Neoplasms / microbiology
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Nasopharynx / microbiology*
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Nucleic Acid Hybridization
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Precancerous Conditions / microbiology
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Repetitive Sequences, Nucleic Acid
Substances
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Antibodies, Viral
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DNA, Viral
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DNA Restriction Enzymes