Two cases of postoperative systemic candidiasis in neurosurgical practice are reported. Postoperatively these patients showed signs and symptoms of systemic infection and unfortunately died in spite of intensive chemotherapy. In both cases systemic candidiasis became evident by histological examinations at autopsy. Long use of antibiotics and aggressive nosocomy were supposed to be the cause of the systemic candidiasis. The authors emphasized a high possibility of opportunistic fungal infection in neurosurgical practice. The symptomatology, treatment and prevention of this disease are also discussed.