WR-2721: enhanced chemoprotection by increasing cyclophosphamide activation with phenobarbitol

Int J Radiat Oncol Biol Phys. 1982 Mar-Apr;8(3-4):571-4. doi: 10.1016/0360-3016(82)90686-1.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amifostine / metabolism
  • Amifostine / pharmacology*
  • Amifostine / toxicity
  • Animals
  • Biotransformation / drug effects
  • Cyclophosphamide / antagonists & inhibitors*
  • Cyclophosphamide / metabolism
  • Cyclophosphamide / toxicity
  • Female
  • Kinetics
  • Organothiophosphorus Compounds / pharmacology*
  • Phenobarbital / pharmacology*
  • Rats
  • Time Factors

Substances

  • Organothiophosphorus Compounds
  • Cyclophosphamide
  • Amifostine
  • Phenobarbital