Assignment of the human phosphoserine phosphatase gene (PSP) to the pter leads to q22 region of chromosome 7

Cytogenet Cell Genet. 1983;35(1):67-9. doi: 10.1159/000131839.

Abstract

Phosphoserine phosphatase (PSP) catalyzes the hydrolysis of phosphoserine to serine. PSP expression has been examined in human-mouse somatic cell hybrids retaining different combination of human chromosomes. Human PSP is expressed only when the pter leads to q22 segment of the human 7 and its enzyme marker beta-glucuronidase (GUSB) are retained in cell hybrids. The structural gene, PSP, is therefore assigned to this region of the human 7.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromosome Mapping
  • Chromosomes, Human, 6-12 and X*
  • Clone Cells
  • Genes*
  • Humans
  • Hybrid Cells / physiology
  • Mice
  • Phosphoric Monoester Hydrolases / genetics*

Substances

  • Phosphoric Monoester Hydrolases
  • phosphoserine phosphatase