Abstract
By analysis of a series of somatic cell hybrids derived by fusion of either mouse or Chinese hamster cells with leukocytes from different chronic myelocytic leukemia (CML) patients or from normal donors, we have localized the human oncogene, c-sis, on the q11 to qter segment of chromosome 22 and demonstrated its translocation from chromosome 22 to chromosome 9 (q34) in CML.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Chromosomes, Human, 21-22 and Y*
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Chromosomes, Human, 6-12 and X*
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Cricetinae
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DNA
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DNA Restriction Enzymes
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DNA, Recombinant
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Humans
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Hybrid Cells / ultrastructure
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Leukemia, Myeloid / genetics*
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Lung Neoplasms / genetics
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Mice
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Nucleic Acid Hybridization
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Oncogenes*
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Sarcoma Virus, Woolly Monkey / genetics
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Translocation, Genetic*
Substances
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DNA, Recombinant
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DNA
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DNA Restriction Enzymes