Abstract
Fourteen adult patients with inoperable soft tissue sarcoma (with metastases in 4 cases) received chemotherapy as primary treatment. Nine cases were treated by CYVADIC (cyclophosphamide, vincristin, doxorubicin, DTIC) and five cases by DECAV (DTIC, cyclophosphamide, cis-platinum, doxorubicin, vindesine). An objective response was obtained in 7 cases (1 complete remission and 6 regressions greater than 50%) and stabilization in 4 cases. Seven patients became operable after 2 to 6 courses of chemotherapy and a complete resection could be performed in 6 cases. The duration of the response was 2 to 39 months. Toxicity with both combinations was acceptable. We conclude that chemotherapy can provide initial tumor reduction and permit subsequently less radical surgery.
Publication types
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Case Reports
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Comparative Study
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English Abstract
MeSH terms
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Adolescent
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Adult
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Aged
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / adverse effects
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Antineoplastic Combined Chemotherapy Protocols*
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Cisplatin / administration & dosage
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Cyclophosphamide / administration & dosage
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Dacarbazine / administration & dosage
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Doxorubicin / administration & dosage
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Drug Therapy, Combination
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Female
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Humans
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Male
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Middle Aged
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Sarcoma / drug therapy*
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Sarcoma / pathology
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Sarcoma / surgery
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Soft Tissue Neoplasms / drug therapy*
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Soft Tissue Neoplasms / pathology
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Soft Tissue Neoplasms / surgery
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Vinblastine / administration & dosage
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Vinblastine / analogs & derivatives
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Vincristine / administration & dosage
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Vindesine
Substances
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Antineoplastic Agents
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Vincristine
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Vinblastine
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Dacarbazine
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Doxorubicin
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Cyclophosphamide
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Cisplatin
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Vindesine
Supplementary concepts
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CYVADIC protocol
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DECAV protocol