Abstract
Five patients with advanced multiresistant neoplasms were infused with NSC-251635 (a water-insoluble antimitotic agent) entrapped in egg yolk lecithin, cholesterol, and stearylamine liposomes. The maximum volume injected was 400 ml containing 8 g of lipids, ie, a dose of 135 mg/kg of body weight. Overall tolerance of the treatment was excellent. This study indicates that liposomes may be used safely as carriers for the iv administration of water-insoluble drugs to humans.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / drug therapy
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Adult
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Antineoplastic Agents / therapeutic use*
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Carcinoma, Small Cell / drug therapy
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Female
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Humans
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Infusions, Parenteral
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Leukemia, Erythroblastic, Acute / drug therapy
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Liposomes / administration & dosage*
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Lung Neoplasms / drug therapy
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Male
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Middle Aged
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Neoplasms / drug therapy*
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Quinazolines / therapeutic use*
Substances
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Antineoplastic Agents
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Liposomes
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Quinazolines
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NSC 251635