Cis-platinum complex with retained prolactin receptor specific binding

Biomed Pharmacother. 1983;37(5):236-9.

Abstract

Two complexes of prolactin and platinum have been synthetized and their biological activity was assayed by radioreceptor assay. Only the cis-platinum prolactin complex retains the capacity of native prolactin to bind to cell receptor membrane. Prolactin could be used to increase the specificity of cis-platinum to cells with prolactin receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cisplatin / metabolism*
  • Humans
  • Kinetics
  • Prolactin / metabolism*
  • Receptors, Cell Surface / metabolism*
  • Receptors, Prolactin

Substances

  • Receptors, Cell Surface
  • Receptors, Prolactin
  • Prolactin
  • Cisplatin