Abstract
The tumor growth inhibitory effect of 5-ethyl-2'-deoxyuridine ( EUdR ) in combination with 5-fluorouracil (5-FU) has been studied on four human colorectal xenograft lines. In all lines the EUdR pretreatment potentiated the effect of 5-FU presumably due to the increased incorporation of 5-FU into RNA via elevated intracellular thymidine concentration and decreased rate of 5-FU catabolism.
MeSH terms
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Adenocarcinoma, Mucinous / drug therapy*
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Animals
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Carcinoma / drug therapy*
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Colonic Neoplasms / drug therapy*
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Deoxyuridine / administration & dosage
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Deoxyuridine / analogs & derivatives*
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Deoxyuridine / therapeutic use
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Drug Synergism
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Fluorouracil / administration & dosage
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Fluorouracil / metabolism
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Fluorouracil / therapeutic use*
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Humans
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Mice
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Mice, Inbred CBA
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Neoplasm Transplantation
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RNA, Neoplasm / metabolism
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Rectal Neoplasms / drug therapy*
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Transplantation, Heterologous
Substances
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RNA, Neoplasm
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edoxudin
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Fluorouracil
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Deoxyuridine