Abstract
Ten new compounds, N-aryl substituted piperazinealkylindanes, have been synthesized. The most active one 1-(2-[4-(3-chlorophenyl)-1-piperazinyl]-ethyl)-indane (compound 9), displayed evident central serotoninolytic properties in the 5-hydroxytryptamine (5-HTP) head twitch test in mice, as well as in the tryptamine convulsions test and the quipazine-stimulated hind paw flexor reflex test in rats.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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5-Hydroxytryptophan / antagonists & inhibitors
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Animals
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Chemical Phenomena
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Chemistry
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Dextroamphetamine / pharmacology
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Indans / chemical synthesis*
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Indans / pharmacology
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Indans / toxicity
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Indenes / chemical synthesis*
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Lethal Dose 50
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Male
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Mice
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Motor Activity / drug effects
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Piperazines / chemical synthesis*
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Piperazines / pharmacology
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Piperazines / toxicity
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Rats
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Rats, Inbred Strains
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Reflex / drug effects
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Reserpine / pharmacology
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Seizures / chemically induced
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Serotonin Antagonists / chemical synthesis*
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Tryptamines / antagonists & inhibitors
Substances
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Indans
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Indenes
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Piperazines
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Serotonin Antagonists
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Tryptamines
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tryptamine
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Reserpine
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5-Hydroxytryptophan
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Dextroamphetamine