Isolate-specific S-antigen of Plasmodium falciparum contains a repeated sequence of eleven amino acids

Nature. 1983;306(5945):751-6. doi: 10.1038/306751a0.

Abstract

Antibodies raised against a Plasmodium falciparum protein expressed in Escherichia coli reacted with a 220,000-molecular weight antigen of mature blood-stage parasites. The protein resembles the sporozoite surface antigen being composed of tandem repeats of 11 amino acids. However, it is isolate-specific and the encoding gene is not detectable in strains that do not express the protein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, Surface* / genetics
  • Base Sequence
  • Genes
  • Isoelectric Point
  • Molecular Weight
  • Plasmodium falciparum / genetics
  • Plasmodium falciparum / immunology*
  • Species Specificity

Substances

  • Antigens, Surface

Associated data

  • GENBANK/X00245